{"id":5558,"date":"2025-10-27T17:50:01","date_gmt":"2025-10-27T17:50:01","guid":{"rendered":"https:\/\/www.isdin.com\/en-US\/blog\/?p=5558"},"modified":"2025-10-27T17:52:38","modified_gmt":"2025-10-27T17:52:38","slug":"what-is-melatonin-how-your-skin-repairs-itself-at-night","status":"publish","type":"post","link":"https:\/\/www.isdin.com\/us\/blog\/isdinnovation\/what-is-melatonin-how-your-skin-repairs-itself-at-night\/","title":{"rendered":"What Is Melatonin? Discover How It Helps Skin Repair Itself at Night"},"content":{"rendered":"<span class=\"span-reading-time rt-reading-time\" style=\"display: block;\"><span class=\"rt-label rt-prefix\">Reading:<\/span> <span class=\"rt-time\"> 4<\/span> <span class=\"rt-label rt-postfix\">minutes<\/span><\/span>\n<p><br>When you think of melatonin, a good night\u2019s rest probably comes to mind. But it\u2019s time to get to know it a little differently.\u00a0Science shows that\u00a0<strong>melatonin is more than a sleep aid\u2014it\u2019s a <em>beauty<\/em> sleep essential.<\/strong><\/p>\n\n\n\n<p>As it turns out, your skin produces its own melatonin at night to help it recover from daily stress. And with this in mind, you might start noticing it on the ingredient list of some of your favorite nighttime skincare formulas. But how does it work? What role does melatonin play in happy, healthy, <em>rested<\/em> skin?<\/p>\n\n\n\n<p>Let\u2019s explore how your skin repairs itself at night, <strong>and how melatonin can lend a helping hand.<\/strong><\/p>\n\n\n\n<p><\/p>\n\n\n\n<blockquote class=\"wp-block-quote has-text-align-center is-layout-flow wp-block-quote-is-layout-flow\" id=\"h-the-basics\">\n<p><strong>THE BASICS<\/strong><\/p>\n<\/blockquote>\n\n\n\n<pre class=\"wp-block-preformatted\"><strong>MELATONIN (MLT)<\/strong><br><br><mark style=\"background-color:rgba(0, 0, 0, 0);color: rgb(0, 0, 0);\" class=\"has-inline-color\"><strong style=\"\">WHAT <\/strong><\/mark><mark style=\"background-color:rgba(0, 0, 0, 0);color:#000000\" class=\"has-inline-color\"><strong>IT IS<\/strong><\/mark><mark style=\"background-color:rgba(0, 0, 0, 0);color: rgb(0, 0, 0);\" class=\"has-inline-color\"><strong style=\"background-color: rgba(0, 0, 0, 0);\">:<\/strong> <\/mark>A naturally-occurring hormone with powerful antioxidant properties.<mark style=\"background-color:rgba(0, 0, 0, 0);color:#090101\" class=\"has-inline-color\"><br><br><strong>WHAT IT DOES: <\/strong><\/mark>\u00a0Topical melatonin helps boost the skin\u2019s nightly repair process, supports well-aging, and minimizes damage caused by daily stressors such as UV rays and pollution.<mark style=\"background-color:rgba(0, 0, 0, 0);color:#090101\" class=\"has-inline-color\"><br><br><strong>WHO IT'S FOR:<\/strong> <\/mark>Suitable for all skin types, it\u2019s especially loved by those looking for visible repair, firmness, and antioxidant protection.<mark style=\"background-color:rgba(0, 0, 0, 0);color:#090101\" class=\"has-inline-color\"><br><br><strong>HOW TO USE IT:<\/strong> <\/mark>Look for it in nighttime eye creams, serums, and moisturizers where it complements skin\u2019s own melatonin production. <mark style=\"background-color:rgba(0, 0, 0, 0);color:#090101\" class=\"has-inline-color\"><br><br><strong>GOES WELL WITH:<\/strong> <\/mark>Vitamin C, carnosine, and retinoids can enhance melatonin\u2019s rejuvenating effects.<mark style=\"background-color:rgba(0, 0, 0, 0);color:#090101\" class=\"has-inline-color\"><br><br><strong>DON\u2019T MIX WITH:<\/strong> <\/mark>This gentle ingredient fits right into any PM routine. <mark style=\"background-color:rgba(0, 0, 0, 0);color:#090101\" class=\"has-inline-color\"><br><br><strong>TRY IT IN:<\/strong> <\/mark><a href=\"https:\/\/www.isdin.com\/us\/p\/vital-eyes\/3862\">Vital Eyes<\/a>, <a href=\"https:\/\/www.isdin.com\/us\/p\/melatonik\/2962\">Melatonik\u00ae\ufe0f<\/a>, <a href=\"https:\/\/www.isdin.com\/us\/p\/retinal-advanced\/4357\">Retinal Advanced<\/a>, <a href=\"https:\/\/www.isdin.com\/us\/p\/age-contour-night\/3954\">Age Contour Night<\/a><br><\/pre>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What is melatonin? <\/h2>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"1200\" height=\"618\" src=\"data:image\/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==\" data-src=\"https:\/\/www.isdin.com\/us\/blog\/wp-content\/uploads\/2021\/08\/image-4.jpeg\" alt=\"Reading in bed\" class=\"wp-image-10376 lazyload\"\/><\/figure>\n\n\n\n<p><\/p>\n\n\n\n<p>You sink into bed and close your eyes after a long day.&nbsp;As you drift off, your body begins its natural repair mode\u2014and one of the key players behind this process is melatonin.<\/p>\n\n\n\n<p><strong data-l-s=\"20120\">Melatonin is a naturally<\/strong><strong> <\/strong><strong data-l-s=\"20120\">occurring hormone<\/strong>. Its main function? Helping to regulate the sleep-wake cycle. Your body\u2019s circadian rhythm kicks off its production at night to help you get to sleep.<\/p>\n\n\n\n<p>But that&#8217;s not its only role. Melatonin is also important to the gut, thyroid, lungs, kidneys, and you guessed it, the skin, where it shows off two main strengths: <strong>antioxidant and repairing actions.<\/strong><\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-what-role-does-melatonin-play-in-the-skin\">What role does melatonin play in the skin?<\/h3>\n\n\n\n<p>At night, as your skin switches from protect mode to repair mode, melatonin production kicks into gear to help it recover from the day\u2019s stresses. And this is no small feat. Your skin makes even more melatonin to <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29428440\/\" target=\"_blank\" rel=\"noreferrer noopener\">help repair itself<\/a> than your brain does to help you fall asleep.<\/p>\n\n\n\n<p>What\u2019s its role exactly? <strong>Melatonin supports skin regeneration and antioxidant activity<\/strong>, helping neutralize free radicals (unstable molecules that can damage cells and accelerate visible aging).<\/p>\n\n\n\n<p>By reducing oxidative stress, melatonin helps support collagen, elasticity, and an even tone\u2014key for smoother, youthful-looking skin.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-how-does-topical-melatonin-work\">How does topical melatonin work?<\/h2>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"1200\" height=\"618\" src=\"data:image\/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==\" data-src=\"https:\/\/www.isdin.com\/us\/blog\/wp-content\/uploads\/2021\/08\/image-5.jpeg\" alt=\"Topical melatonin: how does it work at night?\" class=\"wp-image-10377 lazyload\"\/><\/figure>\n\n\n\n<p><\/p>\n\n\n\n<p>Topical melatonin works similarly to the melatonin your skin produces naturally. <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC6802208\/\" target=\"_blank\" rel=\"noreferrer noopener\">Research shows<\/a> that it supports overnight recovery and helps <strong>prepare your skin\u2019s defenses for the coming day<\/strong>.<\/p>\n\n\n\n<p>In skincare products, melatonin acts as\u00a0an antioxidant. As it sinks into the skin, it helps repair damage accumulated during the day.<\/p>\n\n\n\n<p>Something else to keep in mind? Natural melatonin levels decrease with age, so using topical formulas in your skincare routine can lend a helping hand. <strong>And especially at night\u2014here\u2019s why:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Your skin\u2019s circadian rhythm:<\/strong> Nighttime is when collagen production and skin renewal peak.<\/li>\n\n\n\n<li><strong>Increased permeability:<\/strong> The <a href=\"https:\/\/www.isdin.com\/us\/blog\/skincare\/what-is-the-skin-barrier\/\">skin barrier<\/a> becomes more permeable at night, allowing products to get to work right away.<\/li>\n\n\n\n<li><strong>Fewer external stressors:<\/strong> No sun, minimal pollution\u2014the perfect environment for repair.<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">Who is melatonin for?<\/h3>\n\n\n\n<p>Whatever your <a href=\"https:\/\/www.isdin.com\/us\/blog\/skincare\/how-to-identify-your-skin-type\/\">skin type<\/a>, there\u2019s a place for melatonin in your routine. But&nbsp;it\u2019s especially beneficial for those focused on well-aging or skin recovery.<\/p>\n\n\n\n<p>How come? Targeted melatonin products work in harmony with your body\u2019s natural overnight processes to promote smoother, healthier-looking skin.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-what-other-skincare-ingredients-go-well-with-melatonin\">What other skincare ingredients go well with melatonin?<\/h2>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"1200\" height=\"618\" src=\"data:image\/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==\" data-src=\"https:\/\/www.isdin.com\/us\/blog\/wp-content\/uploads\/2024\/11\/What-other-skincare-ingredients-go-well-with-melatonin_.jpg\" alt=\"What other skincare ingredients go well with melatonin_\" class=\"wp-image-11588 lazyload\"\/><\/figure>\n\n\n\n<p><\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-melatonin-vitamin-c\">Melatonin + vitamin C<\/h3>\n\n\n\n<p>These two powerful antioxidants work together to help your skin fight against daily stressors. <a href=\"https:\/\/www.isdin.com\/us\/blog\/lifestyle\/nutrition\/7-things-you-didnt-know-about-vitamin-c\/\">Vitamin C<\/a> reinforces the skin\u2019s building blocks while helping to brighten and protect. Combined with melatonin, it enhances the skin\u2019s natural defenses and boosts overnight repair\u2014in other words, <strong>the ideal pair for radiant, revitalized skin.<\/strong><\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-melatonin-carnosine\">Melatonin + carnosine<\/h3>\n\n\n\n<p>Ever heard of <a href=\"https:\/\/www.isdin.com\/us\/blog\/skincare\/carnosine-benefits-for-sagging-skin\/\">L-carnosine<\/a>? This natural antioxidant dipeptide helps slow the processes that break down key skin proteins. When paired with melatonin, <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32915393\/\" target=\"_blank\" rel=\"noreferrer noopener\">science shows<\/a> it can help maintain firmness and <strong>combat visible signs of aging<\/strong>.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-melatonin-retinal\">Melatonin + retinal<\/h3>\n\n\n\n<p><a href=\"https:\/\/www.isdin.com\/us\/blog\/isdinnovation\/complete-guide-to-retinal\/\">Retinal<\/a> works hard to improve texture, minimize visible wrinkles, and promote even tone. When combined with melatonin, it reinforces antioxidant protection and promotes skin repair for a complete rejuvenating effect.\u00a0In other words,\u00a0it\u2019s a powerful well-aging duo.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-your-melatonin-skincare-routine-step-by-step\">Your melatonin skincare routine, step by step<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-step-1-use-a-gentle-oil-cleanser\">Step 1: Use a gentle oil cleanser<\/h3>\n\n\n\n<p>Reach for an oil formula to help melt away daily skin stressors. Cleansing oil binds to unwanted oils, makeup, and sunscreen to help eliminate them while adding some much-needed hydration and antioxidant support. Plus, a <a href=\"https:\/\/www.isdin.com\/us\/blog\/skincare\/facial-cleansing-essential-skincare-guide\/\">thorough cleanse<\/a>&nbsp;<strong>leaves the skin ready for your melatonin products to get to work.<\/strong><\/p>\n\n\n\n<p><strong>Tip:<\/strong> On heavier makeup days, or when your skin feels like it needs a little extra care, opt for a <a href=\"https:\/\/www.isdin.com\/us\/blog\/skincare\/double-cleansing-guide\/\">double cleanse<\/a>. Follow your oil cleanser with a <a href=\"https:\/\/www.isdin.com\/us\/p\/isdinceutics-essential-scrub\/4320\">gel scrub<\/a> or <a href=\"https:\/\/www.isdin.com\/us\/p\/isdinceutics-essential-purifier\/4684\">gentle foam<\/a>.<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><a href=\"https:\/\/www.isdin.com\/us\/p\/essential-cleansing\/4041\"><img loading=\"lazy\" decoding=\"async\" width=\"1200\" height=\"618\" src=\"data:image\/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==\" data-src=\"https:\/\/www.isdin.com\/us\/blog\/wp-content\/uploads\/2025\/10\/Gentle-oil-cleanser.jpg\" alt=\"Gentle oil cleanser\" class=\"wp-image-11583 lazyload\"\/><\/a><\/figure>\n\n\n\n<p><\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-step-2-apply-a-revitalizing-eye-contour-cream\">Step 2: Apply a revitalizing eye contour cream<\/h3>\n\n\n\n<p>The eye area is delicate and often the first to show signs of fatigue. Choose a formula that blends reparative melatonin with energizing caffeine to help boost antioxidant defenses while you rest.<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><a href=\"https:\/\/www.isdin.com\/us\/p\/vital-eyes\/3862\"><img loading=\"lazy\" decoding=\"async\" width=\"1200\" height=\"618\" src=\"data:image\/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==\" data-src=\"https:\/\/www.isdin.com\/us\/blog\/wp-content\/uploads\/2024\/11\/Vital-Eyes-melatonin-eye-cream.jpg\" alt=\"Vital Eyes melatonin eye cream\" class=\"wp-image-11589 lazyload\"\/><\/a><\/figure>\n\n\n\n<p><\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-step-3-turn-to-a-serum-starring-melatonin\">Step 3: Turn to a serum starring melatonin<\/h3>\n\n\n\n<div class=\"wp-block-media-text is-stacked-on-mobile\"><figure class=\"wp-block-media-text__media\"><a href=\"https:\/\/www.isdin.com\/us\/p\/melatonik\/2962\"><img loading=\"lazy\" decoding=\"async\" width=\"500\" height=\"572\" src=\"data:image\/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==\" data-src=\"https:\/\/www.isdin.com\/us\/blog\/wp-content\/uploads\/2024\/11\/Melatonin-nighttime-skin-serum.jpeg\" alt=\"Melatonin nighttime skin serum\" class=\"wp-image-11590 size-full lazyload\"\/><\/a><\/figure><div class=\"wp-block-media-text__content\">\n<p><\/p>\n\n\n\n<p><strong>For gentle rejuvenation: <\/strong>Enter\u00a0<a href=\"https:\/\/www.isdin.com\/en-US\/face-care\/3-in-1-night-serum-isdinceutics-melatonik-8429420114609.html\">Melatonik\u00ae\ufe0f<\/a>. This 3-in-1\u00a0serum containing melatonin, <a href=\"https:\/\/www.isdin.com\/us\/blog\/isdinnovation\/what-is-bakuchiol-retinol-alternative\/\">bakuchiol<\/a>, and vitamin C\u00a0boosts natural antioxidant defenses and helps to restore vitality and elasticity, for radiant, healthy skin. The best part? It delivers overnight recovery action while still being gentle.<\/p>\n<\/div><\/div>\n\n\n\n<p><\/p>\n\n\n\n<p><\/p>\n\n\n\n<div class=\"wp-block-media-text has-media-on-the-right is-stacked-on-mobile\"><div class=\"wp-block-media-text__content\">\n<p><\/p>\n\n\n\n<p><strong>For wrinkle-smoothing action:<\/strong> If you\u2019re ready to combine melatonin with the power of retinoids, look no further than <a href=\"https:\/\/www.isdin.com\/us\/p\/retinal-advanced\/4357\">Retinal Advanced<\/a>. This youth-boosting night serum helps visibly reduce wrinkles and fine lines.<\/p>\n<\/div><figure class=\"wp-block-media-text__media\"><a href=\"https:\/\/www.isdin.com\/us\/p\/retinal-advanced\/4357\"><img loading=\"lazy\" decoding=\"async\" width=\"1000\" height=\"1144\" src=\"data:image\/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==\" data-src=\"https:\/\/www.isdin.com\/us\/blog\/wp-content\/uploads\/2021\/08\/2024_11_Melatonina_IMG09.jpg\" alt=\"ISDIN Retinal melatonin serum\" class=\"wp-image-10375 size-full lazyload\"\/><\/a><\/figure><\/div>\n\n\n\n<h3 class=\"wp-block-heading\">Step 4: Reach for a rejuvenating night cream<\/h3>\n\n\n\n<p>After applying your serum, it is time to \u201cseal in\u201d the action with a moisturizer that works to nourish, calm, and firm the skin. Even better if your night cream combines melatonin with amino acids such as&nbsp;<a href=\"https:\/\/www.isdin.com\/en-US\/blog\/skincare\/carnosine-benefits-for-sagging-skin\/\">carnosine<\/a>. Carnosine works to fight&nbsp;<a href=\"https:\/\/www.isdin.com\/en-US\/blog\/skincare\/moisturizers\/whats-glycation-and-how-to-fight-it\/\">glycation<\/a>, a natural process that causes the skin to lose its firmness as we age.<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><a href=\"https:\/\/www.isdin.com\/us\/p\/age-contour-night\/3954\"><img loading=\"lazy\" decoding=\"async\" width=\"1200\" height=\"618\" src=\"data:image\/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==\" data-src=\"https:\/\/www.isdin.com\/us\/blog\/wp-content\/uploads\/2024\/11\/Overnight-melatonin-skincare-cream.jpg\" alt=\"Overnight melatonin skincare cream\" class=\"wp-image-11591 lazyload\"\/><\/a><\/figure>\n\n\n\n<p><\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-step-5-settle-in-for-a-good-night-s-sleep\">Step 5: Settle in for a good night\u2019s sleep<\/h3>\n\n\n\n<p>Your body\u2019s natural melatonin production thrives in darkness\u2014so dim the lights, put your phone away, and enjoy a calming bedtime ritual. A good night\u2019s sleep is essential for both <strong>skin repair and overall wellness<\/strong>.<\/p>\n\n\n\n<p>And remember, you don\u2019t have to follow every step perfectly every night. Start with one, and little by little, you\u2019ll create your own version of a <a href=\"https:\/\/www.isdin.com\/us\/blog\/skincare\/routines\/nighttime-skincare-routine-step-by-step\/\">dreamy nighttime routine<\/a>\u2014one that helps your skin wake up renewed.<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"1200\" height=\"618\" src=\"data:image\/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==\" data-src=\"https:\/\/www.isdin.com\/us\/blog\/wp-content\/uploads\/2024\/11\/Sleep-is-good-for-your-skin.jpg\" alt=\"Sleep is good for your skin\" class=\"wp-image-11592 lazyload\"\/><\/figure>\n\n\n\n<p><\/p>\n\n\n\n<p style=\"font-size:10px\"><strong>Sources and references:<\/strong><br>Chen, Y., Lyga, J. Brain-Skin Connection: Stress, Inflammation and Skin Aging. In <em>Inflammation &amp; Allergy Drug Targets <\/em>(2014); 13(3): 177-190.<br>Matsui, MS., Pelle, E., Dong, K., Pernodet, N. Biological Rhythms in the Skin. In <em>International Journal of Molecular Sciences<\/em> (2016); 17(6): 801. <\/p>\n","protected":false},"excerpt":{"rendered":"<p>As it turns out, your skin produces its own melatonin at night. But how does it work? And what role does topical melatonin play in happy, healthy, rested skin? Find out.<\/p>\n","protected":false},"author":68,"featured_media":10371,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"image","meta":{"_uag_custom_page_level_css":"","footnotes":""},"categories":[1833,370],"tags":[1398],"class_list":["post-5558","post","type-post","status-publish","format-image","has-post-thumbnail","hentry","category-ingredients","category-isdinnovation","tag-ingredients","post_format-post-format-image"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v25.4 (Yoast SEO v25.5) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Melatonin: Benefits and How to include in your Skincare Routine | ISDIN<\/title>\n<meta name=\"description\" content=\"Melatonin has been getting a lot of attention recently, and rightfully so. 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