Retinal Advanced

Dual-phase night serum with retinaldehyde


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Retinal Advanced is a youth-boosting night serum that helps visibly reduce wrinkles and fine lines. Designed with an innovative dual-phase technology, it combines the power of retinaldehyde, melatonin and bakuchiol with Soothing Complex at the moment of application. Add it gradually into your PM routine to unveil smooth, rejuvenated skin after 4 weeks.

1.7 FL OZ (50 ml)

All skin types

Non-comedogenic, mineral oil free, not recommended for use during pregnancy

Fines lines and wrinkles, loss of firmness and elasticity, dullness

Retinaldehyde, melatonin, bakuchiol, Soothing Complex

Make way for dreamy skin
Rejuvenate your skin while dreaming with our dual-phase night serum, designed to combat wrinkles and boost skin renewal.
Reduces wrinkles and fine lines, smoothing the skin for a younger-looking complexion.
Promotes gentle skin surface turnover, helping improve the skin’s overall texture and appearance.
Hydrates and calms the skin, minimizing the sensation of dryness.
Visible reduction in appearance of wrinkles after 3 months of use¹


After 4 weeks, clinical results showed¹:
After 3 months, consumers noticed¹:
Renewed skin
Firmer skin
No discomfort
Reduction of wrinkles and fine lines
¹Data on file. ISDIN Corp. 2023. Morristown, NJ.


Powerful ingredients combined in two unique phases
A derivative of vitamin A, it supports collagen production and skin renewal, while also helping unify complexion.
When applied topically, it acts as an indirect antioxidant, stimulating natural defenses against harmful free radicals
Of natural origin, it demonstrates retinol-like properties, gently helping restore elasticity and firmness.
Soothing Complex
Ultra-soothing ingredients, including niacinamide, work together to hydrate, calm and revitalize the skin.

How to use

Your youth-boosting night serum
Apply at night onto clean and dry skin. Press the pump twice to dispense the right amount into the palm of your hand, mix well, and apply. Massage serum onto your face and neck, avoiding the eye area. The next morning, make sure to always apply a broad spectrum sunscreen, such as Eryfotona Actinica or Eryfotona Ageless.
If it’s your first time using a retinoid, we recommend being mindful of the retinization period. Start by applying it three nights a week. In the second week, apply it four nights. Then, if you haven’t noticed any discomfort in the third week, feel free to up application to seven nights a week.
1. Cleanse
Apply morning and night onto clean, dry skin.
2. Massage
Press two pumps into the palm of your hand, mix well then massage into face and neck, avoiding the eye area.
3. Protect
Always use in combination with broad spectrum sunscreen the following morning, reapplying during the day as directed on the label.
Add Retinal Advanced to your routine
Include Retinal Advanced in your nighttime routine for smooth, rejuvenated skin.
Wash your face with your go-to cleanser.
Eye cream
Massage your eye cream into the eye contour.
Boost your routine with Retinal Advanced.
Face cream
Apply a hydrating face cream to lock in moisture.
Sun protection
Protect your skin with your daily sunscreen.


Is Retinal Advanced suitable for sensitive skin?
Yes! It’s suitable for all skin types. Retinal Advanced has been clinically tested on a wide range of skin types, including sensitive skin.
Can I use it day and night?
The use of retinoids can make the skin more sensitive to external factors, meaning that the effect of sun exposure can be more intense. For this reason, we recommend using it at night, followed by a broad spectrum sunscreen in the morning, reapplying during the day as directed on the label.
What is retinization?
Retinization is the time it may take your skin to adapt to retinoids (like retinaldehyde and retinol). When introducing Retinal Advanced into your routine, it’s recommended to start slow: use it three nights at week at first, then four nights the following week, going up to seven nights in the third week. If you notice prolonged discomfort, limit use and if discomfort persists, consult your dermatologist.
Why is it a dual-phase texture?
Its dual-phase formula separates the oil phase (rejuvenating ingredients) from the aqueous phase (soothing ingredients). Phases are separated in the package to help preserve the effectiveness and stability of the formula. They are combined at the moment of application.
Can it be used during pregnancy or lactation?
If you are pregnant or nursing, consult your doctor prior to use.
Can retinal be combined with vitamin C?
Yes! If you want to incorporate the two ingredients into your daily routine, it’s best to start with one first and introduce the other after a while. We’d recommend using a vitamin C formula, like Flavo-C or Flavo-C Ultraglican, in the morning and Retinal Advanced at night.
What’s the difference between retinal and retinol?
While both are retinoids, retinal (or retinaldehyde) is closer to retinoic acid (the prescription form) than retinol, meaning it has a higher activity.
Retinal Advanced

Retinal Advanced

Dual-phase night serum with retinaldehyde